Project acronym: LIVERHOPE

Project full title: "Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis"

Publications


1. Pere Ginès, Aleksander Krag, Juan G Abraldes, Elsa Solà, Núria Fabrellas, and Patrick S Kamath.

Cirrhosis of the Liver

Lancet 2021. Accepted for publication.


2. Cristina Solé, Susie Guilly, Kevin Da Silva, Marta Llopis, Emmanuelle Le-Chatelier, Patricia Huelin, Marta Carol, Rebeca Moreira, Núria Fabrellas, Gloria De Prada, Laura Napoleone, Isabel Graupera, Elisa Pose, Adrià Juanola, Natalia Borruel, Magali Berland, David Toapanta, Francesc Casellas, Francisco Guarner, Jöel Doré, Elsa Solà, Stanislav Dusko Ehrlich, and Pere Ginès.

pdf Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Gastroenterology 2021;160:206–218. doi: https://doi.org/10.1053/j.gastro.2020.08.054


3. Jonel Trebicka, Jane Macnaughtan, Bernd Schnabl, Debbie L. Shawcross, Jasmohan S. Bajaj.

pdf The microbiota in cirrhosis and its role in hepatic decompensation

J Hepatol 2021 Jul;75 Suppl 1:S67-S81. doi: 10.1016/j.jhep.2020.11.013.


4. Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka.

pdf Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

JHEP Rep 2021 Mar 3;3(3):100264. doi: 10.1016/j.jhepr.2021.100264. eCollection 2021 Jun.


5. Philip Ferstl, Jonel Trebicka.

pdf Acute Decompensation and Acute-on-Chronic Liver Failure

Clinics in Liver Disease 2021 25/2 419-430. doi: 10.1016/j.cld.2021.01.009.


6. Jonel Trebicka, Wenyi Gu, Victor de Ledinghen, Christophe Aubé, Aleksander Krag, Michael Praktiknjo, Laurent Castera, Jerome Dumortier, David Josef Maria Bauer, Mireen Friedrich-Rust, Stanislas Pol, Ivica Grgurevic, Rongqin Zheng, Sven Francque, Halima Gottfriedovà, Sanda Mustapic, Ioan Sporea, Annalisa Berzigotti, Frank Erhard Uschner, Benedikt Simbrunner, Maxime Ronot, Christophe Cassinotto, Maria Kjaergaard, Filipe Andrade, Martin Schulz, Georg Semmler, Ida Tjesic Drinkovic, Johannes Chang, Maximilian Joseph Brol, Pierre Emmanuel Rautou, Thomas Vanwolleghem, Christian P Strassburg, Jerome Boursier, Philip Georg Ferstl, Ditlev Nytoft Rasmussen, Thomas Reiberger, Valerie Vilgrain, Aymeric Guibal, Olivier Guillaud, Stefan Zeuzem, Camille Vassord, Xue Lu, Luisa Vonghia, Renata Senkerikova, Alina Popescu, Cristina Margini, Wenping Wang, Maja Thiele, Chrisitan Jansen.

pdf Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Gut 2021 Jan 21;gutjnl-2020-323419. doi: 10.1136/gutjnl-2020-323419. Online ahead of print.


7. Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka.

pdf Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Gut 2021 Feb;70(2):379-387. doi: 10.1136/gutjnl-2019-320170. Epub 2020 Apr 2.


8. Gabriel Mezzano, Adria Juanola, Andres Cardenas, Esteban Mezey, James P Hamilton, Elisa Pose, Isabel Graupera, Pere Ginès, Elsa Solà, Ruben Hernaez.

pdf Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

Gut 2021 Jan 12; gutjnl-2020-322161. doi: http://dx.doi.org/10.1136/gutjnl-2020-322161


9. Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru.

pdf Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

JHEP Reports 2021 Volume 3, Issue 2 doi: https://doi.org/10.1016/j.jhepr.2021.100233


10. Paolo Caraceni, Victor Vargas, Elsa Solà, Carlo Alessandria, Koos de Wit, Jonel Trebicka, Paolo Angeli, Rajeshwar P. Mookerjee, François Durand, Elisa Pose, Aleksander Krag, Jasmohan S. Bajaj, Ulrich Beuers, Pere Ginès.

pdf The use of Rifaximin in Patients with Cirrhosis

Hepatology 2021 Jan 9. doi: 10.1002/hep.31708. Online ahead of print.


11.Solà E, Pose E, Campion D, Piano S, Roux O, Simon-Talero M, Uschner F, de Wit K, Zaccherini G, Alessandria C, Beuers U, Caraceni P, Francoz C, Mookerjee R, Trebicka J, Vargas V, Serra M, Torres F, Montagnese S, Krag A, Hernáez R, Korenjak M, Watson H, Abraldes JG, Kamath P, Ginès P; LiverHope Consortium Investigators.

pdf ENDPOINTS AND DESIGN OF CLINICAL TRIALS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS: POSITION PAPER OF THE LIVERHOPE CONSORTIUM

J Hepatol 2021, January, Volume 74, Issue 1, Pages 200-219, https://doi.org/10.1016/j.jhep.2020.08.009


12. Katharina Maria Schwarzkopf, Larissa Eberle, Frank Erhard Uschner, Sabine Klein, Robert Schierwagen, Marcus Maximilian Mücke, Liliana Schaefer, Joan Clària, Stefan Zeuzem, Edith Hintermann, Urs Christen, Christian Markus Lange, Jonel Trebicka, Christoph Welsch.

pdf Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

J Hepatol 2020 Oct;73(4):980-982. doi: 10.1016/j.jhep.2020.05.012. Epub 2020 Jul 19.


13. Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein.

pdf Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Int J Mol Sci 2020 May 7;21(9):3308. doi: 10.3390/ijms21093308.


14. Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo.

pdf Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Liver Transpl 2020 Jul;26(7):906-915. doi: 10.1002/lt.25788.


15. Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg.

pdf Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

PLoS One 2020 Apr 17;15(4):e0231701. doi: 10.1371/journal.pone.0231701. eCollection 2020.


16. Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann.

pdf Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Front Immunol 2020 Mar 11;11:354. doi: 10.3389/fimmu.2020.00354. eCollection 2020.


17. Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna.

pdf Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Liver Transpl 2020 Feb;26(2):283-293. doi: 10.1002/lt.25678. Epub 2020 Jan 6.


18. Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka.

pdf Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Liver Int 2020 Jan;40(1):186-193. doi: 10.1111/liv.14230. Epub 2019 Sep 10.


19. Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka.

pdf Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Gut 2020 Aug;69(8):1535-1536. doi: 10.1136/gutjnl-2019-319044. Epub 2019 Jul 3.


20. Michael Praktiknjo, Sofia Monteiro, Josephine Grandt, Nina Kimer, Jan L. Madsen, Mikkel P. Werge, Peter William, Maximilian J. Brol, Laura Turco, Robert Schierwagen, Johannes Chang, Sabine Klein, Frank E. Uschner, Christoph Welsch, Richard Moreau, Filippo Schepis, Flemming Bendtsen, Lise L. Gluud, Søren Møller, Jonel Trebicka.

pdf Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure

Liver International 2020 , 40/6, 1457-1466. doi: 10.1111/liv.14433.


21. Fabrellas N, Carol M, Palacio E, Aban M, Lanzillotti T, Nicolao G, Chiappe MT, Esnault V, Graf‐Dirmeier S, Helder J, Gossard A, Lopez M, Cervera M, Dols LL, The LiverHope consortium investigators.

pdf Nursing care of patients with cirrhosis

Hepatology 2020 Jan 16. doi: 10.1002/hep.31117


22. Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange.

pdf Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

PLoS One 2019 Oct 23;14(10):e0222840. doi: 10.1371/journal.pone.0222840. eCollection 2019.


23. Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus.

pdf Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

J. Clin. Med. 2019, 8(4), 419. doi: https://doi.org/10.3390/jcm8040419


24. Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka.

pdf Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Clinical and Translational Gastroenterology 01 Apr 2019, 10(4):e00025. doi: 10.14309/ctg.0000000000000025.


25. Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka..

pdf Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Hepatol Commun 2019 Jan 22;3(3):340-347. doi: 10.1002/hep4.1308. eCollection 2019 Mar.


26. Solé C, Solà E, Ginés P.

pdf Are we ready to evaluate adrenal function in patients with decompensated cirrhosis and acute-on-chronic liver failure?

Clin Gastroenterol Hepatol. 2019 Nov 20. doi: 10.1016/j.cgh.2019.11.031


27. Pose E, Napoleone L, Amin A, Campion D, Jimenez C, Piano S, Roux O, Uschner FE, de Wit K, Zaccherini G, Alessandria C, Angeli P, Bernardi M, Beuers U, Caraceni P, Durand F, Mookerjee RP, Trebicka J, Vargas V, Andrade RJ, Carol M, Pich J, Ferrero J, Domenech G, Llopis M, Torres F, Kamath PS, Abraldes JG, Solà E, Ginès P.

pdf Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial.

Lancet Gastroenterol Hepatol. 2019 Oct 10. doi: 10.1016/S2468-1253(19)30320-6


28. Solé C, Solà E, Huelin P, Carol M, Moreira R, Cereijo U, Mas JM, Graupera I, Pose E, Napoleone L, dePrada G, Juanola A, Fabrellas N, Torres F, Morales‐Ruiz M, Farrés J, Jiménez W,  Ginès P.

pdf Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival

Liver Int. 2018 Dec 29. doi: 10.1111/liv.14037


29. Pose E, Trebicka J, Mookerjee RP, Angeli P, Ginès P.

pdf Statins: Old drugs as new therapy for liver diseases?

J Hepatol. 2018 Aug.


30. Ginès P, Shiv, S.

pdf More Than Meets the Eye in Using Interleukin 6 as a Marker of Inflammation and Prognostic Factor for Patients With Cirrhosis.

Clinical Gastroenterology and Hepatology. 2018;16:630-632.


31. Solé C, Pose E, Solà E, Ginès P.

pdf Hepatorenal syndrome in the era of acute kidney injury.

Liver Int. 2018;00:1-11.


32. Hernaez R, Solà E, Moreau R, Ginès P.

pdf Acute-on-chronic liver failure: an update.

Gut. 2017 Mar;66(3):541-553. doi: 10.1136/gutjnl-2016-312670. Epub 2017 Jan 4.


33. Solà E, Ginès P.

pdf Pro: Acute-on-chronic liver failure.

Liver Transpl. 2017 Jul 8. doi: 10.1002/lt.24812.